Browse active challenges from the government

Test your research idea about drug use, misuse, and substance abuse disorder (SUD).

Develop new ideas and prototypes that could help people explore and work on the Moon, Mars, and beyond. Apply now.

Develop comics to help reduce health risks and pressure to meet society’s beauty standards.

Design new ways to improve aircraft maintenance, and make aviation safer, more efficient, or more affordable.

Help shape the future of human spaceflight. U.S.-based college students: learn more and apply.

Develop human-based non-animal methods (NAMs) – including lab-based human cell systems, computer models, and biochemical assays.

Help improve in silico models for predicting toxicity using high-quality, open datasets.

High school students: showcase your understanding of civics and knowledge of America’s founding.

Propose a new way to develop more affordable and adaptable all-up-round (AUR) missiles.

Develop programmable delivery systems and non-viral delivery across the blood-brain barrier.